Agmatine treatment inhibited LPS-induced production of nitrates dose dependently. Dhiwaakar Purusothaman Soundiah Regunathan Rajasekaran A Thesis Presented in Partial Fulfilment of the Requirements for the Degree Master of Science Approved April 2016 by the Graduate Supervisory Committee: Nathan G. Chronic migraine (15 or more headache days per month) affects 2 of the adults. There are 2 professionals named 'Soundar Regunathan', who use LinkedIn to exchange information, ideas, and opportunities.
To determine if the decrease in body temperature is associated with an anti-inflammatory effect of agmatine, the nitrite/nitrate levels in plasma was measured. Episodic migraine headaches affect a large percentage of the population (17 of women and 6 of men), account for most pain-related emergency room visits, and may persist as a chronic and disabling condition that extends throughout the lifespan. View the profiles of professionals named 'Soundar Regunathan' on LinkedIn. When agmatine (80 mg/kg) was administered 30 min later than LPS (500 μg/kg) it also inhibited LPS-induced hyperthermia although the effect became significant only at later time points and lower maximal response compared to simultaneous administration. While agmatine itself had no effect on body temperature, treatment with agmatine (20, 40, 80 mg/kg intraperitoneally) dose dependently inhibited stress- and LPS-induced hyperthermia. Rats were either restrained for 4 h or injected with LPS, both of these stressors caused an increase in body temperature. The aim of the present study was to investigate the effect of agmatine on different models of stressors on body temperature. This response seems to share similar mechanisms with infectious fever. Physiological stress evokes a number of responses, including a rise in body temperature, which has been suggested to be the result of an elevation in the thermoregulatory set point. Song of the Spirit : The World of Sacred Music by Sudhamahi Regunathan (Ed.). Soundar Regunathan Agmatine is an amine that is formed by decarboxylation of L-arginine by the enzyme arginine decarboxylase (ADC) and hydrolyzed by the enzyme agmatinase to putrescine.
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